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A multivariate logistic regression was performed to evaluate the effects of genetic polymorphisms on the toxicity control of PK (and vice versa).

Because the Cmin was significantly associated with a rash of grade ≥ 2 (Table 2) and Cmin levels captured most of the associations between polymorphisms and PK (Table 3), this variable was chosen as pharmacokinetic parameters for the multivariate analysis. The results are presented in Table 5 for the eruption and Table 6 of diarrhea. Due to small purchase soma no prescription Houston numbers, multivariate analysis of diarrhea grade ≥ 2 was not performed. Higher levels of C min were associated withincreased risk of rash of grade ≥ 2, the likely increase in eruption about 1.8 times for every 1 mg / dL increase in the level of depression. A significant effect was detected EGFR intron 1 (CA) n repeat (≥ grade 2 rash) which is associated with allele length S / L with an increased risk of toxicity from s / s (p = 0.044). There was also a marginal association (P = 0.070) between the CYP3A4 and rashes on the skin with a reduced risk of G / G compared purchase soma no prescription Houston to A / A. The ABCG2 1143 C / T polymorphism is associated with a slightly lower risk destout rash grade (p = 0.086), and G-16702 / A polymorphism also confers a lower risk of any grade (p purchase soma no prescription Houston = 0.048) or high grade (p = 0.050) eruption. No statistically significant association was found between Cmin and diarrhea, only a marginal association (P = 0.10) for control of EGFR 497 G purchase soma no prescription Houston / A. Patients with genotype G / G CYP3A5estaban higher risk of diarrhea of ​​any grade (p = 0.070) and 15 622 patients with C / T polymorphism (P = 0.057). This prospective study was conducted purchase soma no prescription Houston to assess the clinical impact of diarrhea and rash on the number of genetic polymorphisms that we and others have identified the genes encoding the target of purchase soma no prescription Houston erlotinib, as well as genes related to membrane transport and metabolism.7 8, 13,17,18,33,41 Our results indicate that the determinants purchase soma no prescription Houston of erlotinib toxicity may include the skin with the plasma concentration and variability of EGFR intron polymorphism ( P = 0.034 and P = 0.044, respectively, in a multivariate model).